Herpangina (also known as mouth blisters or vesicular pharyngitis) is typically caused by Coxsackie group A viruses. In few cases it can be triggered by Coxsackie group B infection and echoviral infection. All these viruses are the members of Enterovirus genus and Picornaviridae family.

Coxsackie herpangina is a severe febrile pharyngitis. It affects predominantly babies and young children.

There is an abrupt onset of fever and sore throat with discrete vesicles on the posterior half of the palate, pharynx, tonsils, or tongue. The vesicles progress into ulcerations that heal spontaneously in 7-8 days.

The disorder is self-limited and resolves in 1-2 weeks.

Diagnosis rests on clinical findings; virus isolation is usually not required.

The treatment of herpangina is symptomatic; specific antiviral therapy is absent.