Difference Between Tobramycin and Terramycin

QuestionsCategory: Difference BetweenDifference Between Tobramycin and Terramycin
Biology Ease Staff asked 2 years ago
TobramycinTerramycin
Drug ClassAminoglycoside antibioticTetracycline antibiotic
Mechanism of ActionInhibits bacterial protein synthesisInhibits bacterial protein synthesis
Spectrum of ActivityGram-negative bacteria (including Pseudomonas aeruginosa)Broad-spectrum activity against both Gram-positive and Gram-negative bacteria, as well as some protozoa
Common UsesTreatment of severe bacterial infections, particularly those caused by multidrug-resistant Gram-negative bacteriaTreatment of various bacterial infections, including respiratory tract infections, urinary tract infections, and skin infections
Route of AdministrationIntravenous, inhalation, topical (eye drops)Oral, topical (ointment, eye ointment), injection (for veterinary use)
Resistance ConcernsResistance can develop over time with prolonged useResistance can develop over time with prolonged use
Adverse EffectsNephrotoxicity, ototoxicity (ear toxicity), neuromuscular blockade (with high doses)Gastrointestinal disturbances, photosensitivity (increased sensitivity to sunlight), allergic reactions
Precautions/WarningsRequires monitoring of kidney function and hearing during treatmentAvoid use in children under 8 years old (may cause tooth discoloration), caution in patients with liver or kidney impairment, may reduce effectiveness of oral contraceptives
Drug InteractionsCan interact with other medications that affect kidney function or cause hearing damageCan interact with other medications, antacids, and supplements that may reduce its absorption
Pregnancy CategoryCategory D (may cause harm to the fetus)Category D (may cause harm to the fetus)
Trade NamesTobrex, NebcinTerramycin, Oxytetracycline