Difference Between Tobramycin and Terramycin

QuestionsCategory: Difference BetweenDifference Between Tobramycin and Terramycin
Biology Ease Staff asked 8 months ago
Tobramycin Terramycin
Drug Class Aminoglycoside antibiotic Tetracycline antibiotic
Mechanism of Action Inhibits bacterial protein synthesis Inhibits bacterial protein synthesis
Spectrum of Activity Gram-negative bacteria (including Pseudomonas aeruginosa) Broad-spectrum activity against both Gram-positive and Gram-negative bacteria, as well as some protozoa
Common Uses Treatment of severe bacterial infections, particularly those caused by multidrug-resistant Gram-negative bacteria Treatment of various bacterial infections, including respiratory tract infections, urinary tract infections, and skin infections
Route of Administration Intravenous, inhalation, topical (eye drops) Oral, topical (ointment, eye ointment), injection (for veterinary use)
Resistance Concerns Resistance can develop over time with prolonged use Resistance can develop over time with prolonged use
Adverse Effects Nephrotoxicity, ototoxicity (ear toxicity), neuromuscular blockade (with high doses) Gastrointestinal disturbances, photosensitivity (increased sensitivity to sunlight), allergic reactions
Precautions/Warnings Requires monitoring of kidney function and hearing during treatment Avoid use in children under 8 years old (may cause tooth discoloration), caution in patients with liver or kidney impairment, may reduce effectiveness of oral contraceptives
Drug Interactions Can interact with other medications that affect kidney function or cause hearing damage Can interact with other medications, antacids, and supplements that may reduce its absorption
Pregnancy Category Category D (may cause harm to the fetus) Category D (may cause harm to the fetus)
Trade Names Tobrex, Nebcin Terramycin, Oxytetracycline