Biology Ease Staff asked 2 years ago
- Salicylate therapy can cause G.I. bleeding resulting in haematemesis and anemia.
- Salicylates in large doses reduce the plasma prothrombin level causing hypoprothrombinaemia.
- At low doses, the disturbance in blood clotting is due to interference with prostaglandin synthesis.
- Hypoprothrombinaemia and hemorrhagic complications can be prevented or treated with simultaneous administration of vitamin K.
- Hence, salicylate therapy is always supported by vitamin K.