Difference Between Glomerular and Tubular Proteinuria

QuestionsCategory: Difference BetweenDifference Between Glomerular and Tubular Proteinuria
Biology Ease Staff asked 10 months ago


Glomerular Proteinuria Tubular Proteinuria
Location Glomerulus (part of the kidney) Renal tubules (part of the kidney)
Mechanism Increased glomerular permeability Impaired tubular reabsorption
Protein Types Primarily albumin (large proteins) Various low molecular-weight proteins
Urine Protein High levels Variable levels
Selectivity Selective proteinuria (mostly albumin) Non-selective proteinuria
Clinical Features Edema, hypoalbuminemia Polyuria, electrolyte abnormalities
Renal Pathology Glomerular damage Tubular dysfunction
Causes Glomerulonephritis, diabetic nephropathy, systemic lupus erythematosus Tubular damage, acute tubular necrosis, drug-induced nephrotoxicity
Diagnostic Tests Urine protein electrophoresis, urine protein-to-creatinine ratio Urine microscopy, renal biopsy
Treatment Treat underlying cause, manage symptoms Treat underlying cause, supportive care


It’s important to note that glomerular and tubular proteinuria can coexist in some kidney diseases, and a thorough evaluation is necessary to determine the underlying cause. Additionally, the clinical presentation and management may vary depending on the specific condition and individual patient factors. It is always recommended to consult with a healthcare professional for an accurate diagnosis and appropriate treatment.