Difference Between Hepatocellular and Obstructive Jaundice

QuestionsCategory: Difference BetweenDifference Between Hepatocellular and Obstructive Jaundice
Biology Ease Staff asked 8 months ago

 

Hepatocellular Jaundice Obstructive Jaundice
Definition Jaundice caused by liver cell dysfunction Jaundice caused by obstruction of bile flow
Site of Problem Dysfunction of hepatocytes (liver cells) Blockage in the bile ducts or bile flow
Bilirubin Level Elevated direct (conjugated) and indirect (unconjugated) bilirubin levels Elevated direct (conjugated) bilirubin level, normal or mildly elevated indirect (unconjugated) bilirubin level
Serum Alkaline Phosphatase Level May be mildly elevated or normal Markedly elevated
Urine Bilirubin Positive for conjugated bilirubin (urobilinogen) Positive for conjugated bilirubin (urobilinogen)
Stool Color Normal or pale (acholic) stools Dark-colored (normal or clay-colored) stools
Liver Function Tests Variable abnormalities (e.g., elevated liver enzymes, abnormal coagulation profile) Variable abnormalities (e.g., elevated liver enzymes, abnormal coagulation profile)
Causes Hepatitis, cirrhosis, drug-induced liver injury, alcoholic liver disease Gallstones, tumors, strictures, biliary atresia
Imaging Studies Ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI) Ultrasonography, CT, MRI, endoscopic retrograde cholangiopancreatography (ERCP)
Treatment Management of underlying liver disease or causative factors Treatment of the underlying cause, relief of bile duct obstruction (surgical or endoscopic intervention)